All Studies · Pain & Somatic Conditions · Murray (2022)

Murray (2022)

Low · Pilot RCT · Promising (Pilot RCT) · n = 29
Quality Index (Adjusted QI) 0.689
0 Low < 0.56 Moderate 0.56–0.77 High ≥ 0.78 1
Study Details
ConditionPost-Lyme disease
Clinical domainPain & Somatic Conditions
PopulationPost-treatment Lyme disease
Sample sizen = 29
Country / SettingUSA - Lyme disease specialty clinic
Protocol clusterGeneral/Varied KY
Duration8 weeks; weekly 1.5-hour group sessions (groups of 4-6); daily home practice (35-min unverified)
Control typeWaitlist
ComparatorWaitlist control
Outcomes & Effect Sizes
Primary outcomePain/Somatic symptoms
Scales usedPain scales; fatigue measures; adherence
Key resultPain decreased; fatigue decreased; adherence confirmed
Effect sized = 0.44 (pain); small-moderate effect
ES value0.44 (d)
Retention82% (18/22 completed)
SafetyNo adverse events; well-tolerated in chronic condition
View PDF
Methodological Summary

Pilot RCT; specific condition (Lyme); small sample

KY Protocol Components

Kundalini Yoga for Post-Treatment Lyme Disease Syndrome (PTLDS): Pilot RCT DESIGN: Pilot RCT; KY (small groups) vs. waitlist control (WLC). POPULATION: Patients with persistent pain or fatigue after treated Lyme disease. Target n=40; actual n=29. DURATION: 8 weekly group sessions, 1.5 hours each. GROUP SIZE: 4-6 participants per group. INSTRUCTOR: Study investigator (CA), certified KY instructor with >500 hours training; Southport, CT. KY PROTOCOL: • Light stretching with rhythmical movements • Directed breathing • Guided meditation • Described in Appendix A of paper MATERIALS: Paper copy of stretching exercises, guided meditation CD/MP3, daily practice log. HOME PRACTICE: All aspects of protocol encouraged daily; duration documented. OUTCOMES: Primary — pain, pain interference, fatigue, global health. Secondary — multisystem symptom burden, mood, sleep, physical/social functioning, cognition, mindfulness.

Quality Item Scores — 1 fail · 2 partial · 3 pass · ★ critical
★A1
3
A2
3
★B1
2
★B2
2
B3
3
B4
2
★B5
1
B6
2
★B7
2
★B8
3
B9
2
★C1
1
C2
1
C3
1
JP1
3
Critical fails2
Raw QI0.689
SAF1
Adjusted QI0.689
Final ratingLow